Tolerance is the gradual reduction in response to a substance after repeated use, so that the same amount produces a smaller effect over time. It is a general pharmacological concept that applies to many everyday substances, including caffeine.
For why kratom tolerance happens and how people manage it, read the full guide: Kratom Tolerance →
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Disclaimer: This glossary entry is for educational purposes only and is not intended as medical, legal,
or professional advice. Kratom is not approved by the FDA to diagnose, treat, cure, or prevent any disease.