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Both Kratom and CBD are popular hallucinogenic substances that are commonly used throughout Asia and the middle east. Since they have been around for a while now, it is natural for people to experiment with their use. One such experiment resulted in a popular cocktail called 4*100. This cocktail originated in Thailand and consists of a mixture of Kratom with caffeinated drinks/ cough syrup or CBD oil. This mixture produces a potent, longer-lasting high than either ingredient does when used separately. The effects of the mixture differ depending upon the type of Kratom it is combined with. This tells us that it is possible to combine Kratom with CBD. To gain a deeper understanding of how these two substances complement each other and how to do it safely? First, we must understand their chemistry and properties. 
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How Kratom Will Affect The Human Body
Kratom or Mitragyna Speciosa is a plant that is native to Thailand and other regions of southeast Asia. It is known for the mellow high in produces in the user. it is widely used in the southeastern part of Asia and is gaining a following in the USA also. This is partly because it is not regarded as an illegal drug or a controlled substance. In the US, cannabis use is already widespread. However, unlike cannabis, Kratoms side effects have not been as extensively documented in the medical literature. The effects of Kratom differ depending upon the strain used. The common categories of Kratom are as follows, their effects on the human body can vary.
We will later focus on how these Kratom strains act in combination with cannabis, for now, let us consider CBD individually.
How Cannabis Will Affect The Human Body
Cannabis comes from the Cannabaceae family. It is a flowering plant that has many different types. Hemp is one such type. CBD is a cannabidiol compound. It is derived from the hemp plant. The hemp plant is used for harvesting purposes because it has a higher proportion of cannabis oil. It is a very useful material with different industrial uses. Not only does its high CBD content lend itself to medical/ psychotropic use. Byproducts from the Hemp plant are used to produce clothing, footwear, and paper products, while its waste material can be used for cheap, biodegradable insulation. The hemp plant is grown on special farms, and it has a proportionately higher CBD to THC ratio. THC aka, Tetrahydrocannabinol is a psychoactive compound. THC is only present in very trace quantities in cultivated hemp and these levels do not produce a detectible high on their own. However other cannabinoids in the plant work together with THC to produce the Entourage effect. The Entourage effect essentially balances the human body’s endocannabinoid system. This produces an overall balancing effect on all the bodily processes without exerting any undue psychoactive effect. This balancing effect is what has made cannabis such a popular form of alternative therapy. Especially for those suffering from chronic, debilitating illnesses. CBD can be bought as capsules, tinctures, tea, or liquid. There is even a 99% pure CBD crystal, that isolates pure CBD from THC. This crystal isolate promotes balance in the physical body without any high at all. These days people use CBD in many creative ways, and occasionally as a mixture, which is why it is essential to ask this question. Is it possible to combine Kratom with CBD and If it is? How can we do it safely?
How Do Kratom and CBD Differ & Why?
Kratom and CBD both affect the human body in different ways. This difference in effect is due to the uniquely different biochemistry of both plant species. Kratom is different from CBD on a chemical and molecular level as it is composed of mitragynine and 7-hydroxy mitragynine, which are alkaloids. Hemp, from which CBD is derived is composed mostly of CBD and acts on the endocannabinoid system in the human body which promotes overall balance in all bodily processes. Thereby enhancing well-being holistically. CBD comprises up to 40% of the Hemp plant and is it’s major chemical active. It is reasonable to assume that these two substances, when used together will work synergistically to produce both balance and promote relaxation.
What Will Happen When I Combine Both Cannabis and Kratom
From the above, we have already concluded that it is indeed possible to combine Kratom and CBD. Since their overlapping effects have a positive overall influence on the body. Kratom will function as a mood enhancer while CBD will complement this function by balancing the physical bodily processes. This will enhance the overall wellbeing of the user and contribute to his or her well-being. Generally speaking, this mixture is considered safe but to ensure that we know how to do it safely. We must now explore how they function together. Since Kratom has a more potent effect than CBD from a psychoactive perspective. The CBD and Kratom cocktail effect depends mostly on the vein of Kratom used in the cocktail.
How To Do It Safely?
When administering any mixture of this sort it is necessary to know which plants work well together and which could have a harmful effect. It is also important to focus on the quality of ingredients used. Like any hallucinogenic it is wise to start with smaller quantities, working up to a minimally effective dose. Experimentation is required to find out which strains or varieties work well together and which combination is of most benefit to you. It is important to remember that this mixture might not suit everyone. Everyone is different and may have a different reaction to it and his or her physical response is dependent on a combination of factors.
How & When To Use Your Kratom/CBD Mixture?
It is recommended that you use this mixture in a safe place and in a trusted company. Obviously, as with other mood enhancers, it is not recommended to drive or use heavy machinery while using mood enhancers. It is also important to start with small amounts to avoid over-dosing.
Conclusion
Overall, it is safe to say that not only is it possible to combine Kratom and CBD, but it could also be very beneficial to the user if he/she knows how to do it safely. Since Kratom and CBD function in a manner which complements each other with the benefits of one being enhanced by the other. 
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